References

Badia JM, Casey AL, Petrosillo N Impact of surgical site infection on healthcare costs and patient outcomes: a systematic review in six European countries. J Hosp Infect. 2017; 96:(1)1-15 https://doi.org/10.1016/j.jhin.2017.03.004

Arora A, Bharadwaj P, Chaturvedi H A review of prevention of surgical site infections in Indian hospitals based on global guidelines for the prevention of surgical site infection, 2016. Journal of Patient Safety and Infection Control. 2018; 6:(1)1-12 https://doi.org/10.4103/jpsic.jpsic_29_17

Leaper DJ, Edmiston CE. World Health Organization: global guidelines for the prevention of surgical site infection. J Hosp Infect. 2017; 95:(2)135-136 https://doi.org/10.1016/j.jhin.2016.12.016

Tartari E, Weterings V, Gastmeier P Patient engagement with surgical site infection prevention: an expert panel perspective. Antimicrob Resist Infect Control. 2017; 6 https://doi.org/10.1186/s13756-017-0202-3

Cañedo-Dorantes L, Cañedo-Ayala M. Skin acute wound healing: a comprehensive review. Int J Inflam. 2019; 2019 https://doi.org/10.1155/2019/3706315

Koehler J, Brandl FP, Goepferich AM. Hydrogel wound dressings for bioactive treatment of acute and chronic wounds. Eur Polym J. 2018; 100:1-11 https://doi.org/10.1016/j.eurpolymj.2017.12.046

Wuthisuthimethawee P, Lindquist SJ, Sandler N Wound management in disaster settings. World J Surg. 2015; 39:(4)842-853 https://doi.org/10.1007/s00268-014-2663-3

Feng P, Luo Y, Ke C Chitosan-based functional materials for skin wound repair: mechanisms and applications. Front Bioeng Biotechnol. 2021; 9 https://doi.org/10.3389/fbioe.2021.650598

Zhou L, Cai L, Ruan H Electrospun chitosan oligosaccharide/polycaprolactone nanofibers loaded with wound-healing compounds of Rutin and Quercetin as antibacterial dressings. Int J Biol Macromol. 2021; 183:1145-1154 https://doi.org/10.1016/j.ijbiomac.2021.05.031

Liu H, Wang C, Li C A functional chitosan-based hydrogel as a wound dressing and drug delivery system in the treatment of wound healing. RSC Advances. 2018; 8:7533-7549 https://doi.org/10.1039/C7RA13510F

Takeuchi Y, Kurashima Y, Nakanishi Y Mesh trimming and suture reconstruction for wound dehiscence after huge abdominal intercostal hernia repair: a case report. Int J Surg Case Rep. 2018; 53:381-385 https://doi.org/10.1016/j.ijscr.2018.11.028

Udpa N, Iyer SR, Rajoria R Effects of chitosan coatings on polypropylene mesh for implantation in a rat abdominal wall model. Tissue Eng Part A. 2013; 19:(23-24)2713-2723 https://doi.org/10.1089/ten.tea.2012.0739

Tomioka K, Fujioka T, Satoh T Delayed mesh infection and mesh penetrating the transverse colon and small intestine after abdominal incisional hernia repair. J Surg Case Rep. 2020; 2020:(10) https://doi.org/10.1093/jscr/rjaa409

Amit A, Srivastava KN. Mesh related infections in hernia surgery: a case report and review of literature. ARC Journal of Surgery. 2018; 4:(3)19-23

Matica MA, Aachmann FL, Tøndervik A Chitosan as a wound dressing starting material: antimicrobial properties and mode of action. Int J Mol Sci. 2019; 20:(23) https://doi.org/10.3390/ijms20235889

Bano I, Arshad M, Yasin T Chitosan: a potential biopolymer for wound management. Int J Biol Macromol. 2017; 102:380-383 https://doi.org/10.1016/j.ijbiomac.2017.04.047

Deng Z, Wang T, Chen X, Liu Y. Applications of chitosan-based biomaterials: a focus on dependent antimicrobial properties. Mar Life Sci Technol. 2020; 2:398-413 https://doi.org/10.1007/s42995-020-00044-0

Okamoto Y, Kawakami K, Miyatake K Analgesic effects of chitin and chitosan. Carbohydr Polym. 2002; 49:(3)249-252 https://doi.org/10.1016/S0144-8617(01)00316-2

Use of chitosan wound dressing for the treatment of surgical site infection: a case report

01 March 2023

Abstract

Surgical site infections (SSIs) are treated using topical antiseptics and systemic antibiotics, but some cases are unresponsive to such regimens. This case study reports the effective healing of an SSI by a chitosan wound dressing (MaxioCel; Axio Biosolutions Private Limited, India) in a 63-year-old female patient. The patient presented with an infected, hard-to-heal wound in the abdominal region, developed after a hernia surgery, and was initially treated with standard procedures. However, due to the continuous progression of infection, a highly absorbent, bioactive microfibre dressing was selected for the treatment and was continued for two months with alternate-day dressing changes. After 60 days of treatment, wound healing was observed, along with remission from the infection, as well as reduction in exudate level and pain. The use of chitosan wound dressing in management of hard-to-heal infected wounds provides efficient remission of SSI and a faster healing rate.

Surgical site infection (SSI) is the most common hospital-acquired infection in Europe1 and is even more common in India.2 The numbers indicate an incidence of 23–38% in India compared with 0.5–15% in Europe. The incidence of SSI is generally influenced by factors such as pre- and post-operative care, the theatre environment and the type of surgery. The World Health Organization (WHO) recommends simple hand preparation with soap alone as adequate in preventing SSI.3 Even though strong precautions are taken in the pre-operative and theatre environment, it is also important to have patient engagement in post-operative care of surgical wounds.4

An acute wound is acquired as a result of an incision or trauma and usually heals in a timely and orderly manner. After injury, the healing process consists of four major phases: the initial and late inflammatory phases, the proliferative phase and the remodelling phase.5 As exposed wounds are prone to infection they are generally cleansed or debrided before treatment. Traditionally, wounds were treated by protecting them against infection and leaving them for natural mechanisms to take charge of healing. However, in recent years there have been many advances in the area of wound care.

Register now to continue reading

Thank you for visiting Journal of Wound Care's World Union of Wound Healing Supplement and reading some of our peer-reviewed resources for healthcare professionals. To read more, please register today.