References

International Diabetes Federation. Atlas de la diabetes de la FID. 2019. https://tinyurl.com/wyzu2jht (accessed 12/08/21)

Gobierno de Chile. Ministerio de Salud. Norma clínica: Manejo integral del pie diabético. Resolución Exenta N° 395. 2006. https://tinyurl.com/y4c9p25a (accessed 12/08/21)

Seguel G. ¿Por qué debemos preocuparnos del pie diabético? Importancia del pie diabético. Rev Med Chile. 2013; 141:1464-1469

Use of collagen and negative pressure wound therapy on a diabetic foot ulcer: a case study

01 March 2022

Abstract

This case study describes the combined use of a wound contact layer dressing containing collagen with negative pressure wound therapy (NPWT) on a diabetic foot ulcer (DFU). The patient was treated at a university hospital in Santiago, Chile. A wound size reduction of 58% was observed within the first 10 weeks of treatment, and the wound went on to heal fully over the next 14 weeks. The combined use of collagen and NPWT helped to initiate healing and prevent amputation of the foot. At 64, the patient was able to maintain his independence and quality of life.

There are 463 million people living with diabetes globally, according to the International Diabetes Federation (IDF).1 This figure represents 9.3% of the worldwide population between 20 and 79 years of age, and increases year-on-year.

Diabetes has a negative impact on a patient's quality of life, particularly when a diabetic foot ulcer (DFU) develops. Complications associated with these types of wounds increase the risk of amputation 10–20 times compared to adults without diabetes,2 and are the leading cause of non-traumatic lower-limb amputations. The treatment of DFUs through proper assessment and healing can prevent a large percentage of amputations in patients with diabetes.3 It is therefore crucial to identify innovative diabetic foot healing strategies to promote wound bed closure.

The following case study describes the use of a wound contact layer dressing with collagen and sodium alginate in a sterile sheet (ColActive Transfer, Covalon Technologies Ltd., Ontario, Canada), used in combination with negative pressure wound therapy (NPWT) (XRL8, Genadyne Biotechnologies Inc., New York, US) on a patient with a hard-to-heal DFU.

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