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Using polyvinyl alcohol-ionic hydrogels containing a wound healing agent to manage wounds in different environments

01 August 2022

Research

Abstract

Objective:

To explore the effects of pH on properties of polyvinyl alcohol (PVA)-ionic hydrogels containing wound healing promoters.

Method:

PVA was combined with a natural wound healing promoter (silk sericin (SS)), and an anionic agent (eosin (ES)) or cationic agent (methylene blue (MB)), and made into hydrogels. Properties of the hydrogels and behaviour at different pHs were investigated.

Results:

The density and gel fraction of PVA/SS-ES hydrogel and PVA/SS-MB hydrogel were considerably lower compared with hydrogel without SS. The swelling ratio and degradation of the hydrogels increased with increasing SS concentration in all pH solutions. The influence of SS in interrupting long-chain PVA molecules was confirmed based on changes in Fourier-transform infrared spectroscopy (FTIR). The SS released from the gels was found to interact with the ionic agent and influenced the release profile of the ionic agent. Surprisingly, the anionic agent in PVA/SS-ES hydrogel showed 70% release in high pH solution whereas the cationic agent in PVA/SS-MB hydrogel showed 86% release in low pH solution. Moreover, the active agent could accumulate on the skin layer and had a positive effect on a specific wound area.

Conclusion:

Based on the results obtained in this study, it is suggested to use anionic hydrogels containing wound healing promoter for wounds at high pH and cationic hydrogels containing wound healing promoter for wounds with low pH. Ability to improve wound healing using a natural healing agent combined with ionic agents and controlling the pH of hydrogels will help in developing quick and low-cost treatment for wounds.

Wound management and healing are primary concerns during treatment, with the annual cost for wound healing in the US reported to be more than $25 billion USD.¹ Polymeric wound dressings have gained considerable importance due to their ability to improve wound healing, reduce patient discomfort and treatment costs. Among the different forms of polymers used, hydrogels are preferred for wound healing since they contain >70% water,² and can maintain moisture and promote autolytic debridement, leading to higher comfort and better healing.³

Hydrogels made from natural polymers, such as starch, chitosan or cellulose, and from synthetic polymers, such as polylactic acid (PLA) and polyvinyl alcohol (PVA), are extensively used for wound healing and other medical applications. Self-healing, injectable, cell penetrating and other types of hydrogels have been developed. In addition to polymers, several bioactive agents have been included in the hydrogel to improve its performance and achieve better results. For instance, chitosan, silver nanoparticles and various growth-promoting agents have been incorporated in hydrogels used as wound dressings.⁴

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eosin

hydrogels

ionic

PVA

polyvinyl alcohol

sericin

wound

wound care

wound dressing

wound healing

wound infection